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KMID : 0370220230670040268
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Yakhak Hoeji
2023 Volume.67 No. 4 p.268 ~ p.276
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Real world tablet-splitting prescription status of enteric-coated tablets of diclofenac sodium and aspirin
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Yun Seung-Won
Chun Pu-Soon
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Abstract
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This study aimed to investigate tablet-splitting prescription of enteric-coated tablets of diclofenac sodium andaspirin. We conducted a retrospective cross-sectional study using claims data collected by the Health Insurance Review andAssessment Service (HIRA) of Korea during 2016-2020. Of the 1,227,666 prescriptions of aspirin 100 mg enteric-coatedtablet, 941 tablet-splitting prescriptions were identified, accounting for 0.1%. Of the 941 prescriptions, 41.7% (392) wereprescribed for the elderly individuals aged ?65 years. Of the 334 tablet-splitting cases with 15 or more consecutive daysof prescription, 58.7% (196) were found in the elderly. Furthermore, 37.0% (37/100), 37.1% (13/35), and 40.4% (36/89)of cases with consecutive days of prescription of 31-60, 61-90 days, and more than 90 days, respectively, gastrointestinaldisorders were found. Of the 53,868 prescriptions of diclofenac sodium 25 mg enteric-coated tablet, 2,248 tablet-splittingprescriptions were identified, accounting for 4.2%. Furthermore, of the 2,248 prescriptions, 53.0% (1,192) were prescribedfor children under 5 years old, and 33.1% (744) were prescribed for children aged 5-9 years, respectively. We found thattablet-splitting prescription rate of diclofenac sodium 25 mg was high, especially in children. Gastrointestinal disorderswere common in the tablet-splitting prescriptions of aspirin 100 mg, especially in the cases with 15 or more consecutivedays of prescription.
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KEYWORD
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Aspirin, Diclofenac sodium, Enteric-coated tablet, Tablet-splitting prescription
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